In trials
Call me when the human trials give a positive return
Patience Padawan.
I have 1 autistic kid with T1D and 1 kid with celiac. I’m confident in next 10 years both will be cured.
I’m guessing you mean the diabetes and celiac will be cured, not the autism
Lol yes. I am not a crackpot
This sounds quite exciting and it doesn’t smell like bullshit.
Oh fuck yes! I hope this works so badly (living the nightmare with crohns)
I wonder if it also applies to ulcerative colitis…
What about Hashimoto’s thyroiditis and Graves’ disease?
This looks promising, way more promising than any other cure for MS I’ve read about
If we assume for a moment that it works as advertised - what is it that makes this a vaccine? To me it sounds like a cure or treatment.
It is not a cure for the reasons others in this thread have stated. It doesn’t repair damage already done, it only prevents the disease from advancing. That’s still a huge deal, though.
But when it comes to type 1 diabetes the cause is the body destroying beta cells in the pancreas and everything else is a symptom of that. If you can make the body “forget” killing beta cells (like the article states the anti-vaccine would, or rather teach the body to not kill) then it would make sense for the body to recover and repair the damage done.
Wouldn’t it then be a cure?
@be_excellent_to_each_other @m3t00
Vaccines have evolved from prevention/mitigation to now include treatment, and ideally cures.So skimming through the link, it’s a vaccine because it’s still triggering a specific body response to fight the illness as opposed to directly attacking the illness itself? Is that a reasonable layman’s summary of why it’s called a vaccine?
(Old x’er here, Vaccines have been preventative for as long as I’ve ever known, that’s the reason for the question.)
@be_excellent_to_each_other @m3t00
I an X that had the exact same thoughts lol. I’m no expert, but old vaccines often contained some of the virus live or deactivated, whereas mRNA are created and not of biological origin. So more about the front end than the back end.
The amount of science research funded over COVID that allowed for the rapid development and testing of mRNA technology has created a boon for centuries to come. COVID may well be responsible for the death of autoimmune diseases.
I wonder if a similar technique could be used to reduce organ transplant rejection.
Ehhh, maybe? If I’m reading the article right (and I haven’t yet gone digging past the article to the source itself because that takes more time than I currently have), it’s targeting t cells only. Rejection involves more than just t cells though.
It might be at least partially effective, I’m not trained in the field to be able to predict that much, just basing what I’m saying off of past reading and general information.
I’m not confident in this, though. It’s pretty damn far beyond the level of actual training I’ve had. I can say confidently that the basic techniques they’re talking about should be applicable to more than just autoimmune disorders, just not the degree of efficacy.
There’s just so many more cells involved in something like hyperacute and acute rejection that it’s likely to be something that would have to be more complicated than the already complicated technique they’re working on.
I would say that, if this proves to work in actual humans safely and effectively, that the immune related cancers would be the more probable beneficiaries of the method.
See, most of the autoimmune stuff is a “false positive” the body at some point got fooled by some kind of external agent, that happened to match some part of the body. So, if you wipe out the “memory” of that false positive, the body stops attacking itself.
The cancers that are immune related should respond in a similar way. You’d still have the malignant cells, but it should stop new ones from going crazy, and the usual methods of killing off the existing malignant cells should effectively “cure” the person with drastically reduced chances of relapse.
But with transplants, there’s no false positive. There actually are foreign cells in the body, being constantly exposed to immune cells. There’s also usually more than one kind of cell, so the method they’re using probably would need multiple efforts to work at all, and would likely need to be administered regularly. I’m fairly confident that the method could reduce severity of rejection, but that’s still only fairly lol. But, (disclaimer again), the method should work in either a single or small number of treatments for autoimmune diseases.
I hope like hell this gets into human trials fast. I have a personal stake in it (hence all the reading lol) and what this thing can’t do is undo the damage already done. The person being treated is still going to have whatever degree of disability the disease already caused, so the sooner people can start the treatment, the better off they are.
Most of the diseases explicitly listed as targets for this treatment are fucking brutal. Just one year with MS, as an example, can take someone from healthy and active to being half blind, or unable to walk unaided, or any number of other issues. MS already takes time to diagnose, so pretty much everyone that has it has some degree of disability by the time they start existing treatments. And the existing treatments, as incredible as they are, don’t fully prevent new damage occurring. Nor do all of them work at full efficacy for everyone. You can end up having to try multiple treatments to find the right one for your immune system.
So, most MS patients have a serious amount of time before their disease even gets slowed. My wife, from diagnosis to first partially effective treatment, went almost a year, and lost so damn much from that time plus the effects from before diagnosis. You’re talking someone that was modeling and a jogger being unable to walk down a hallway until over a year of physical therapy, and still can’t handle long walks.
And she didn’t even lose as much as some people do. She also deals with what’s called relapsing/remitting MS (RRMS) which takes breaks between attacks. People with primary progressive MS (PPMS) can lose function faster and more severely. It’s a fucking terrifying disease.
This is starting to go very long and tangential, so I’ll stop after this bit.
I hope like hell it will work for not only the listed diseases, but rejection too. Gods, the lives it could make better if it can do all of that would change the world, along with the individual lives. It would be the scientific equivalent of a miracle cure.
When this was posted before someone who followed it fairly closely and others like it, updated the thread with info because the article was behind current info. They had already stopped the trials for MS because it wasn’t working. So they began to just focus on one other, the Crohn’s, I believe. Figuring if they got one to work, they could go back to the others and get them on the right track.
I have MS, and while this is a new approach, there have been so many articles about treatments that end up going nowhere after the first excitement. So it is still very early to get hopes up.
Hope can be a dangerous thing. Hope can drive a man insane, as Red said.
have Crohn’s. fingers crossed 🤞🏽
I took two doses of Pfizer Covid Vaccine and now I have a heart disease.